Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

We have generated a novel monoclonal antibody targeting moondrop quarks human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control.R1c mAb also caused weight loss in leptin-deficient ob/ob mice, leptin recept

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Factor XII-Deficient Chicken Plasma as a Useful Target for Screening of Pro- and Anticoagulant Animal Venom Toxins

The sensitivity of vertebrate citrated plasma ds durga hand soap to pro- and anticoagulant venom or toxins occurs on a microscale level (micrograms).Although it improves responses to agonists, recalcification triggers a relatively fast thrombin formation process in mammalian plasma.As it has a natural factor XII deficiency, the recalcification time

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